The role of subarachnoid hemorrhage in post-traumatic Seizures: Insights from a retrospective study on TBI and seizure patterns
Objective: Traumatic brain injury (TBI) and post-traumatic seizures (PTS) have been interconnected since ancient times. Modern research emphasizes their impact on morbidity and mortality, with persistent seizures linked to poor cognitive outcomes. PTS complicates recovery, especially when early seiz...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-08-01
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| Series: | Brain Hemorrhages |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589238X25000245 |
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| author | Suleiman Daoud Atef F. Hulliel Rasha S. Mustafa Almutazballlah Qablan Yasmeen Jamal Alabdallat Sa’ed Hasan Nataly Al-zubi Adam M. Abdallah Mohammad Alsharman Amer Jaradat Sultan Jarrar Mohammad A Jamous |
| author_facet | Suleiman Daoud Atef F. Hulliel Rasha S. Mustafa Almutazballlah Qablan Yasmeen Jamal Alabdallat Sa’ed Hasan Nataly Al-zubi Adam M. Abdallah Mohammad Alsharman Amer Jaradat Sultan Jarrar Mohammad A Jamous |
| author_sort | Suleiman Daoud |
| collection | DOAJ |
| description | Objective: Traumatic brain injury (TBI) and post-traumatic seizures (PTS) have been interconnected since ancient times. Modern research emphasizes their impact on morbidity and mortality, with persistent seizures linked to poor cognitive outcomes. PTS complicates recovery, especially when early seizures indicate severe injury. This study explores how different TBI types affect the development of focal versus generalized seizures to improve clinical management. Methods: A retrospective study at King Abdullah University Hospital (KAUH), Jordan, examined 1934 TBI cases from 2017 to 2023, identifying 118 patients with confirmed post-traumatic seizures. Results: Among 118 patients, the median age was 21.5 years (range 2–86), and most were male (74.6 %). Trauma types included Intracerebral Hemorrhage (47.5 %), Subarachnoid Hemorrhage (38.1 %), Intraventricular Hemorrhage (17 %), Subdural Hematoma (28.8 %), Epidural Hematoma (12.7 %), and Skull Fractures (38.1 %). Generalized tonic-clonic seizures occurred in 69.5 %, while 30.5 % were focal. At study end, 84.7 % of patients survived. Binary logistic regression revealed that Subarachnoid Hemorrhage (SAH) significantly increased the likelihood of generalized seizures (odds ratio 3.308, p = 0.005). Other trauma types did not significantly affect seizure type. Conclusion: Subarachnoid hemorrhage (SAH) significantly increases the likelihood of generalized tonic-clonic seizures, suggesting it as a key risk factor. Further research is needed to refine preventive and treatment strategies. |
| format | Article |
| id | doaj-art-db24d4cce0b84f58b38b4c756e266d62 |
| institution | Kabale University |
| issn | 2589-238X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Brain Hemorrhages |
| spelling | doaj-art-db24d4cce0b84f58b38b4c756e266d622025-08-20T04:01:02ZengKeAi Communications Co., Ltd.Brain Hemorrhages2589-238X2025-08-016416216510.1016/j.hest.2025.02.007The role of subarachnoid hemorrhage in post-traumatic Seizures: Insights from a retrospective study on TBI and seizure patternsSuleiman Daoud0Atef F. Hulliel1Rasha S. Mustafa2Almutazballlah Qablan3Yasmeen Jamal Alabdallat4Sa’ed Hasan5Nataly Al-zubi6Adam M. Abdallah7Mohammad Alsharman8Amer Jaradat9Sultan Jarrar10Mohammad A Jamous11Neurosurgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan; Corresponding author at: Jordan University of Science and Technology, Irbid, Jordan.Faculty of Medicine, Jordan University of Science & Technology, PO Box 3030, 22110 Irbid, JordanJordanian Ministry of Health, Irbid, JordanJordanian Ministry of Health, Irbid, JordanFaculty of Medicine, Hashemite University, 13133 Zarqa, JordanFaculty of Medicine, Jordan University of Science & Technology, PO Box 3030, 22110 Irbid, JordanFaculty of Medicine, Jordan University of Science & Technology, PO Box 3030, 22110 Irbid, JordanKing Abdullah University Hospital-JUST, Irbid, JordanKing Abdullah University Hospital-JUST, Irbid, JordanNeurosurgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, JordanNeurosurgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, JordanKing Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid, JordanObjective: Traumatic brain injury (TBI) and post-traumatic seizures (PTS) have been interconnected since ancient times. Modern research emphasizes their impact on morbidity and mortality, with persistent seizures linked to poor cognitive outcomes. PTS complicates recovery, especially when early seizures indicate severe injury. This study explores how different TBI types affect the development of focal versus generalized seizures to improve clinical management. Methods: A retrospective study at King Abdullah University Hospital (KAUH), Jordan, examined 1934 TBI cases from 2017 to 2023, identifying 118 patients with confirmed post-traumatic seizures. Results: Among 118 patients, the median age was 21.5 years (range 2–86), and most were male (74.6 %). Trauma types included Intracerebral Hemorrhage (47.5 %), Subarachnoid Hemorrhage (38.1 %), Intraventricular Hemorrhage (17 %), Subdural Hematoma (28.8 %), Epidural Hematoma (12.7 %), and Skull Fractures (38.1 %). Generalized tonic-clonic seizures occurred in 69.5 %, while 30.5 % were focal. At study end, 84.7 % of patients survived. Binary logistic regression revealed that Subarachnoid Hemorrhage (SAH) significantly increased the likelihood of generalized seizures (odds ratio 3.308, p = 0.005). Other trauma types did not significantly affect seizure type. Conclusion: Subarachnoid hemorrhage (SAH) significantly increases the likelihood of generalized tonic-clonic seizures, suggesting it as a key risk factor. Further research is needed to refine preventive and treatment strategies.http://www.sciencedirect.com/science/article/pii/S2589238X25000245Traumatic brain injuryPost-traumatic seizuresSubarachnoid hemorrhageGeneralized tonic-clonic seizures |
| spellingShingle | Suleiman Daoud Atef F. Hulliel Rasha S. Mustafa Almutazballlah Qablan Yasmeen Jamal Alabdallat Sa’ed Hasan Nataly Al-zubi Adam M. Abdallah Mohammad Alsharman Amer Jaradat Sultan Jarrar Mohammad A Jamous The role of subarachnoid hemorrhage in post-traumatic Seizures: Insights from a retrospective study on TBI and seizure patterns Brain Hemorrhages Traumatic brain injury Post-traumatic seizures Subarachnoid hemorrhage Generalized tonic-clonic seizures |
| title | The role of subarachnoid hemorrhage in post-traumatic Seizures: Insights from a retrospective study on TBI and seizure patterns |
| title_full | The role of subarachnoid hemorrhage in post-traumatic Seizures: Insights from a retrospective study on TBI and seizure patterns |
| title_fullStr | The role of subarachnoid hemorrhage in post-traumatic Seizures: Insights from a retrospective study on TBI and seizure patterns |
| title_full_unstemmed | The role of subarachnoid hemorrhage in post-traumatic Seizures: Insights from a retrospective study on TBI and seizure patterns |
| title_short | The role of subarachnoid hemorrhage in post-traumatic Seizures: Insights from a retrospective study on TBI and seizure patterns |
| title_sort | role of subarachnoid hemorrhage in post traumatic seizures insights from a retrospective study on tbi and seizure patterns |
| topic | Traumatic brain injury Post-traumatic seizures Subarachnoid hemorrhage Generalized tonic-clonic seizures |
| url | http://www.sciencedirect.com/science/article/pii/S2589238X25000245 |
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