F. prausnitzii potentially modulates the association between citrus intake and depression
Abstract Background The gut microbiome modulates the effects of diet on host health, but it remains unclear which specific foods and microbial features interact to influence risk of depression. To understand this interplay, we leveraged decades of dietary and depression data from a longitudinal coho...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Microbiome |
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| Online Access: | https://doi.org/10.1186/s40168-024-01961-3 |
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| _version_ | 1846165077267316736 |
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| author | Chatpol Samuthpongtorn Allison A. Chan Wenjie Ma Fenglei Wang Long H. Nguyen Dong D. Wang Olivia I. Okereke Curtis Huttenhower Andrew T. Chan Raaj S. Mehta |
| author_facet | Chatpol Samuthpongtorn Allison A. Chan Wenjie Ma Fenglei Wang Long H. Nguyen Dong D. Wang Olivia I. Okereke Curtis Huttenhower Andrew T. Chan Raaj S. Mehta |
| author_sort | Chatpol Samuthpongtorn |
| collection | DOAJ |
| description | Abstract Background The gut microbiome modulates the effects of diet on host health, but it remains unclear which specific foods and microbial features interact to influence risk of depression. To understand this interplay, we leveraged decades of dietary and depression data from a longitudinal cohort of women (n = 32,427), along with fecal metagenomics and plasma metabolomics from a substudy (n = 207) nested in this cohort, as well as an independent validation cohort of men (n = 307). Results We report that citrus intake and its components are prospectively associated with a lower risk of depression and altered abundance of 15 gut microbial species, including enriched Faecalibacterium prausnitzii. In turn, we found a lower abundance of F. prausnitzii and its metabolic pathway, S-adenosyl-L-methionine (SAM) cycle I in participants with depression. To explore causality, we found that lower SAM production by F. prausnitzii may decrease intestinal monoamine oxidase A gene expression implicated in serotonin and dopamine synthesis. Conclusions These data underscore the role of diet in the prevention of depression and offer a plausible explanation for how the intestinal microbiome modulates the influence of citrus on mental health. Video Abstract |
| format | Article |
| id | doaj-art-db1b970743a84a6786a57ea12bb21189 |
| institution | Kabale University |
| issn | 2049-2618 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Microbiome |
| spelling | doaj-art-db1b970743a84a6786a57ea12bb211892024-11-17T12:38:12ZengBMCMicrobiome2049-26182024-11-0112111410.1186/s40168-024-01961-3F. prausnitzii potentially modulates the association between citrus intake and depressionChatpol Samuthpongtorn0Allison A. Chan1Wenjie Ma2Fenglei Wang3Long H. Nguyen4Dong D. Wang5Olivia I. Okereke6Curtis Huttenhower7Andrew T. Chan8Raaj S. Mehta9Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical SchoolClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical SchoolClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical SchoolDepartment of Nutrition, Harvard T.H. Chan School of Public HealthClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical SchoolDepartment of Nutrition, Harvard T.H. Chan School of Public HealthDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical SchoolDepartment of Biostatistics, Harvard T.H. Chan School of Public HealthClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical SchoolClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical SchoolAbstract Background The gut microbiome modulates the effects of diet on host health, but it remains unclear which specific foods and microbial features interact to influence risk of depression. To understand this interplay, we leveraged decades of dietary and depression data from a longitudinal cohort of women (n = 32,427), along with fecal metagenomics and plasma metabolomics from a substudy (n = 207) nested in this cohort, as well as an independent validation cohort of men (n = 307). Results We report that citrus intake and its components are prospectively associated with a lower risk of depression and altered abundance of 15 gut microbial species, including enriched Faecalibacterium prausnitzii. In turn, we found a lower abundance of F. prausnitzii and its metabolic pathway, S-adenosyl-L-methionine (SAM) cycle I in participants with depression. To explore causality, we found that lower SAM production by F. prausnitzii may decrease intestinal monoamine oxidase A gene expression implicated in serotonin and dopamine synthesis. Conclusions These data underscore the role of diet in the prevention of depression and offer a plausible explanation for how the intestinal microbiome modulates the influence of citrus on mental health. Video Abstracthttps://doi.org/10.1186/s40168-024-01961-3Gut microbiomeDepressionCitrus fruitsMetagenomicsMetabolomicsTranscriptomics |
| spellingShingle | Chatpol Samuthpongtorn Allison A. Chan Wenjie Ma Fenglei Wang Long H. Nguyen Dong D. Wang Olivia I. Okereke Curtis Huttenhower Andrew T. Chan Raaj S. Mehta F. prausnitzii potentially modulates the association between citrus intake and depression Microbiome Gut microbiome Depression Citrus fruits Metagenomics Metabolomics Transcriptomics |
| title | F. prausnitzii potentially modulates the association between citrus intake and depression |
| title_full | F. prausnitzii potentially modulates the association between citrus intake and depression |
| title_fullStr | F. prausnitzii potentially modulates the association between citrus intake and depression |
| title_full_unstemmed | F. prausnitzii potentially modulates the association between citrus intake and depression |
| title_short | F. prausnitzii potentially modulates the association between citrus intake and depression |
| title_sort | f prausnitzii potentially modulates the association between citrus intake and depression |
| topic | Gut microbiome Depression Citrus fruits Metagenomics Metabolomics Transcriptomics |
| url | https://doi.org/10.1186/s40168-024-01961-3 |
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