Retrospective cohort study to investigate the 10-year trajectories of disease patterns in patients with hypertension and/or diabetes mellitus on subsequent cardiovascular outcomes and health service utilisation: a study protocol
Introduction Hypertension (HT) and diabetes mellitus (DM) and are major disease burdens in all healthcare systems. Given their high impact on morbidity, premature death and direct medical costs, we need to optimise effectiveness and cost-effectiveness of primary care for patients with HT/DM. This st...
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BMJ Publishing Group
2021-02-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/2/e038775.full |
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| author | Carlos King Ho Wong Esther Yee Tak Yu Cindy Lo Kuen Lam Emily Tsui Yee Tse Weng Yee Chin Eric Yuk Fai Wan Julie Chen Tony King Hang Ha David Vai Kiong Chao Wendy Wing Sze Tsui |
| author_facet | Carlos King Ho Wong Esther Yee Tak Yu Cindy Lo Kuen Lam Emily Tsui Yee Tse Weng Yee Chin Eric Yuk Fai Wan Julie Chen Tony King Hang Ha David Vai Kiong Chao Wendy Wing Sze Tsui |
| author_sort | Carlos King Ho Wong |
| collection | DOAJ |
| description | Introduction Hypertension (HT) and diabetes mellitus (DM) and are major disease burdens in all healthcare systems. Given their high impact on morbidity, premature death and direct medical costs, we need to optimise effectiveness and cost-effectiveness of primary care for patients with HT/DM. This study aims to find out the association of trajectories in disease patterns and treatment of patients with HT/DM including multimorbidity and continuity of care with disease outcomes and service utilisation over 10 years in order to identify better approaches to delivering primary care services.Methods and analysis A 10-year retrospective cohort study on a population-based primary care cohort of Chinese patients with documented doctor-diagnosed HT and/or DM, managed in the Hong Kong Hospital Authority (HA) public primary care clinics from 1 January 2006 to 31 December 2019. Data will be extracted from the HA Clinical Management System to identify trajectory patterns of patients with HT/DM. Complications defined by ICPC-2/International Classification of Diseases-Ninth Revision, Clinical Modification diagnosis codes, all-cause mortality rates and public service utilisation rates are included as independent variables. Changes in clinical parameters will be investigated using a growth mixture modelling analysis with standard quadratic trajectories. Dependent variables including effects of multimorbidity, measured by (1) disease count and (2) Charlson’s Comorbidity Index, and continuity of care, measured by the Usual Provide Continuity Index, on patient outcomes and health service utilisation will be investigated. Multivariable Cox proportional hazards regression will be conducted to estimate the effect of multimorbidity and continuity of care after stratification of patients into groups according to respective definitions.Ethics and dissemination This study was approved by the institutional review board of the University of Hong Kong—the HA Hong Kong West Cluster, reference no: UW 19–329. The study findings will be disseminated through peer-reviewed publications and international conferences.Trial registration number NCT04302974. |
| format | Article |
| id | doaj-art-db1a0f7eaba74f9ea5eee63e63be3de8 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-db1a0f7eaba74f9ea5eee63e63be3de82024-11-17T06:00:08ZengBMJ Publishing GroupBMJ Open2044-60552021-02-0111210.1136/bmjopen-2020-038775Retrospective cohort study to investigate the 10-year trajectories of disease patterns in patients with hypertension and/or diabetes mellitus on subsequent cardiovascular outcomes and health service utilisation: a study protocolCarlos King Ho Wong0Esther Yee Tak Yu1Cindy Lo Kuen Lam2Emily Tsui Yee Tse3Weng Yee Chin4Eric Yuk Fai Wan5Julie Chen6Tony King Hang Ha7David Vai Kiong Chao8Wendy Wing Sze Tsui93 Laboratory of Data Discovery for Health Limited (D²4H), Hong Kong Science Park, Hong Kong Special Administrative Region, People`s Republic of ChinaDepartment of Family Medicine and Primary Care, The University of Hong Kong, Hong Kong6 Department of Family Medicine and Primary Care, The University of Hong Kong, Hong Kong SAR, China1 Department of Family Medicine and Primary Care, University of Hong Kong, Hong Kong, China1 Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People`s Republic of ChinaDepartment of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong3 Newborn Research, Royal Women’s Hospital, Parkville, Victoria, Australia3 Primary and Community Services, Hospital Authority, Hong Kong, China5 Department of Family Medicine & Primary Health Care, United Christian Hospital, Kowloon East Cluster, Hospital Authority, Hong Kong, People`s Republic of China5 Family Medicine & Primary Healthcare, Hospital Authority Hong Kong West Cluster, Hong Kong Island, ChinaIntroduction Hypertension (HT) and diabetes mellitus (DM) and are major disease burdens in all healthcare systems. Given their high impact on morbidity, premature death and direct medical costs, we need to optimise effectiveness and cost-effectiveness of primary care for patients with HT/DM. This study aims to find out the association of trajectories in disease patterns and treatment of patients with HT/DM including multimorbidity and continuity of care with disease outcomes and service utilisation over 10 years in order to identify better approaches to delivering primary care services.Methods and analysis A 10-year retrospective cohort study on a population-based primary care cohort of Chinese patients with documented doctor-diagnosed HT and/or DM, managed in the Hong Kong Hospital Authority (HA) public primary care clinics from 1 January 2006 to 31 December 2019. Data will be extracted from the HA Clinical Management System to identify trajectory patterns of patients with HT/DM. Complications defined by ICPC-2/International Classification of Diseases-Ninth Revision, Clinical Modification diagnosis codes, all-cause mortality rates and public service utilisation rates are included as independent variables. Changes in clinical parameters will be investigated using a growth mixture modelling analysis with standard quadratic trajectories. Dependent variables including effects of multimorbidity, measured by (1) disease count and (2) Charlson’s Comorbidity Index, and continuity of care, measured by the Usual Provide Continuity Index, on patient outcomes and health service utilisation will be investigated. Multivariable Cox proportional hazards regression will be conducted to estimate the effect of multimorbidity and continuity of care after stratification of patients into groups according to respective definitions.Ethics and dissemination This study was approved by the institutional review board of the University of Hong Kong—the HA Hong Kong West Cluster, reference no: UW 19–329. The study findings will be disseminated through peer-reviewed publications and international conferences.Trial registration number NCT04302974.https://bmjopen.bmj.com/content/11/2/e038775.full |
| spellingShingle | Carlos King Ho Wong Esther Yee Tak Yu Cindy Lo Kuen Lam Emily Tsui Yee Tse Weng Yee Chin Eric Yuk Fai Wan Julie Chen Tony King Hang Ha David Vai Kiong Chao Wendy Wing Sze Tsui Retrospective cohort study to investigate the 10-year trajectories of disease patterns in patients with hypertension and/or diabetes mellitus on subsequent cardiovascular outcomes and health service utilisation: a study protocol BMJ Open |
| title | Retrospective cohort study to investigate the 10-year trajectories of disease patterns in patients with hypertension and/or diabetes mellitus on subsequent cardiovascular outcomes and health service utilisation: a study protocol |
| title_full | Retrospective cohort study to investigate the 10-year trajectories of disease patterns in patients with hypertension and/or diabetes mellitus on subsequent cardiovascular outcomes and health service utilisation: a study protocol |
| title_fullStr | Retrospective cohort study to investigate the 10-year trajectories of disease patterns in patients with hypertension and/or diabetes mellitus on subsequent cardiovascular outcomes and health service utilisation: a study protocol |
| title_full_unstemmed | Retrospective cohort study to investigate the 10-year trajectories of disease patterns in patients with hypertension and/or diabetes mellitus on subsequent cardiovascular outcomes and health service utilisation: a study protocol |
| title_short | Retrospective cohort study to investigate the 10-year trajectories of disease patterns in patients with hypertension and/or diabetes mellitus on subsequent cardiovascular outcomes and health service utilisation: a study protocol |
| title_sort | retrospective cohort study to investigate the 10 year trajectories of disease patterns in patients with hypertension and or diabetes mellitus on subsequent cardiovascular outcomes and health service utilisation a study protocol |
| url | https://bmjopen.bmj.com/content/11/2/e038775.full |
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