Phosphofructokinase-1 redefined: a metabolic hub orchestrating cancer hallmarks through multi-dimensional control networks
Abstract Phosphofructokinase-1 (PFK-1), the core rate-limiting enzyme of glycolysis, has transcended its classical metabolic regulatory role and emerged as a multi-dimensional hub in tumour biology. This review systematically delineates the dynamic regulatory networks of PFK-1 isoforms (PFKP, PFKL,...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-025-06897-2 |
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