Andrographolide promotes the ex vivo expansion of CD34+ hematopoietic stem cells derived from human umbilical cord blood

Andrographolide promotes the ex vivo expansion of CD34+ hematopoietic stem cells derived from human umbilical cord blood

Abstract Umbilical cord blood (UCB) units are an alternative source of human hematopoietic stem cells (HSCs) for allogeneic stem cell transplants. A large quantity of HSCs is needed but the low number of accessible cells from UCB has been a significant limitation. Improving the ex vivo growth of HSC...

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Main Authors: Nareerat Sutjarit, Laongthip Ruknarong, Chamnan Tanprasertkul, Kanit Bhukhai, Hay Man Saung Hnin Soe, Pakpoom Kheolamai, Sirikul Manochantr, Chairat Tantrawatpan, Duangrat Tantikanlayaporn
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Andrographolide
Hematopoietic stem cells (HSCs)
Ex vivo expansion
Umbilical cord blood (UCB)
Hematologic disorders
Hematopoietic stem cell transplantation
Online Access:https://doi.org/10.1038/s41598-025-15647-9
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https://doi.org/10.1038/s41598-025-15647-9

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