USP5‐Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation

USP5‐Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation

ABSTRACT Mesenchymal stem cell (MSC) transplantation is considered one of the most promising regenerative strategies for treating degenerative musculoskeletal diseases, yet its underlying therapeutic mechanisms remain incompletely understood. In this study, we demonstrate that transplanted MSCs regu...

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Bibliographic Details
Main Authors: Pengzhi Shi, Haiyang Gao, Zhangrong Cheng, Wenbo Wu, Anran Zhang, Xianglong Chen, Wang Wu, Yukun Zhang
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Journal of Extracellular Vesicles
Subjects:
apoptotic extracellular vesicles
DNA damage repair
E2F1
intervertebral disc degeneration
NPCs apoptosis
USP5
Online Access:https://doi.org/10.1002/jev2.70148
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https://doi.org/10.1002/jev2.70148

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