Meta_B cells: a computationally identified candidate immunosuppressive driver of gastric cancer metastasis revealed by single-cell analysis and machine learning

Meta_B cells: a computationally identified candidate immunosuppressive driver of gastric cancer metastasis revealed by single-cell analysis and machine learning

Abstract Background Gastric cancer (GC) metastasis remains a major clinical challenge due to insufficient understanding of tumor microenvironment (TME) dynamics. While B cells are implicated in GC progression, their subset-specific roles in metastatic niches are poorly defined. Methods We analyzed g...

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Bibliographic Details
Main Authors: Tianchi Lei, Yiwen Jiang, Kexin Yang, Chuqi Meng, Yue An
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Discover Oncology
Subjects:
Gastric cancer metastasis
ScRNA-seq
Machine learning prognostic model
Tumor microenvironment
Immune escape
Chemotherapy sensitivity
Online Access:https://doi.org/10.1007/s12672-025-03356-8
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https://doi.org/10.1007/s12672-025-03356-8

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