Intratumoral co‐injection of NK cells and NKG2A‐neutralizing monoclonal antibodies

Intratumoral co‐injection of NK cells and NKG2A‐neutralizing monoclonal antibodies

Abstract NK‐cell reactivity against cancer is conceivably suppressed in the tumor microenvironment by the interaction of the inhibitory receptor NKG2A with the non‐classical MHC‐I molecules HLA‐E in humans or Qa‐1b in mice. We found that intratumoral delivery of NK cells attains significant therapeu...

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Main Authors: Ignacio Melero, Maria C Ochoa, Carmen Molina, Sandra Sanchez‐Gregorio, Saray Garasa, Carlos Luri‐Rey, Sandra Hervas‐Stubbs, Noelia Casares, Edurne Elizalde, Gabriel Gomis, Assunta Cirella, Pedro Berraondo, Alvaro Teijeira, Maite Alvarez
Format: Article
Language:English
Published: Springer Nature 2023-10-01
Series:EMBO Molecular Medicine
Subjects:
HLA‐E
intratumoral immunotherapy
NK
NKG2A
Qa‐1b
Online Access:https://doi.org/10.15252/emmm.202317804
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https://doi.org/10.15252/emmm.202317804

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