Replacing protruding domains of MrNV virus-like particles with sialic acid binding domains enhances binding to SARS-CoV-2 susceptible cells and reduces pseudovirus infection

Replacing protruding domains of MrNV virus-like particles with sialic acid binding domains enhances binding to SARS-CoV-2 susceptible cells and reduces pseudovirus infection

Abstract The SARS-CoV-2 virus continues to pose a public health threat due to its ability to rapidly mutate into multiple variants via mutation in its spike (S1/2) proteins. These mutations can lead to viral variants capable of escaping antibody neutralization. The interaction between the SARS-CoV-2...

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Main Authors: Supawich Boonkua, Orawan Thongsum, Rueangtip Chantunmapitak, Purimpuch Soongnart, Somkid Jaranathummakul, Kitima Srisanga, Patompon Wongtrakoongate, Somluk Asuvapongpatana, Wattana Weerachatyanukul, Atthaboon Watthammawut, Monsicha Somrit
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Virus-like particles (VLPs)
Macrobrachium rosenbergii nodavirus (MrNV)
Nanotechnology
Genetic modification
Online Access:https://doi.org/10.1038/s41598-025-10792-7
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https://doi.org/10.1038/s41598-025-10792-7

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