SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics

SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics

Abstract Background The FDA approval of T cell receptor-engineered T cells (TCR-T) for synovial sarcoma demonstrates the potential for adoptive T cell therapies (ACTs) in solid tumors. However, the paucity of tumor-associated targets without expression in normal tissues remains a major bottleneck, e...

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Main Authors: Stefano Testa, Aastha Pal, Ajay Subramanian, Sushama Varma, Jack Pengfei Tang, Danielle Graham, Sara Arfan, Minggui Pan, Nam Q. Bui, Kristen N. Ganjoo, Sarah Dry, Paul Huang, Matt van de Rijn, Wei Jiang, Anusha Kalbasi, Everett J. Moding
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Genome Medicine
Subjects:
Cellular therapy
CAR-T cells
TCR-T cells
Peptide-centric CAR-T
Logic-gated CAR-T
Single-cell RNA sequencing
Online Access:https://doi.org/10.1186/s13073-025-01514-9
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https://doi.org/10.1186/s13073-025-01514-9

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