Metabolite-mediated interactions and direct contact between Fusobacterium varium and Faecalibacterium prausnitzii
Abstract Background The human gut harbors a diverse microbiota that is crucial for maintaining health but also contributes to several diseases. Understanding how microbial communities are assembled and maintained is critical for advancing gut health. Results We identified a unique interaction betwee...
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BMC
2025-07-01
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| Series: | Microbiome |
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| Online Access: | https://doi.org/10.1186/s40168-025-02168-w |
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| author | Koji Hosomi Satoko Maruyama Tsubasa Matsuoka Mari Furuta Yoko Tojima Keita Uchiyama Makiko Morita Hitoshi Kawashima Toshiki Kobayashi Jun Kunisawa |
| author_facet | Koji Hosomi Satoko Maruyama Tsubasa Matsuoka Mari Furuta Yoko Tojima Keita Uchiyama Makiko Morita Hitoshi Kawashima Toshiki Kobayashi Jun Kunisawa |
| author_sort | Koji Hosomi |
| collection | DOAJ |
| description | Abstract Background The human gut harbors a diverse microbiota that is crucial for maintaining health but also contributes to several diseases. Understanding how microbial communities are assembled and maintained is critical for advancing gut health. Results We identified a unique interaction between the pathobiont Fusobacterium varium and the symbiont Faecalibacterium prausnitzii, both members of the gut microbial community; their interaction is driven by metabolites and direct cell-to-cell contact. Growth of F. varium was inhibited in the presence of F. prausnitzii because of a decrease in pH and an increase in β-hydroxybutyric acid. Conversely, the growth of F. prausnitzii was promoted in the presence of F. varium, likely via direct contact. Conclusions These findings highlight the importance of metabolite-driven interactions and direct contact in shaping gut microbial communities and emphasize the potential of interactions between F. prausnitzii and F. varium in influencing gut health. Video Abstract |
| format | Article |
| id | doaj-art-d9e355d39a534480b4f9dcff6bc2a039 |
| institution | Kabale University |
| issn | 2049-2618 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Microbiome |
| spelling | doaj-art-d9e355d39a534480b4f9dcff6bc2a0392025-08-20T03:46:15ZengBMCMicrobiome2049-26182025-07-0113111210.1186/s40168-025-02168-wMetabolite-mediated interactions and direct contact between Fusobacterium varium and Faecalibacterium prausnitziiKoji Hosomi0Satoko Maruyama1Tsubasa Matsuoka2Mari Furuta3Yoko Tojima4Keita Uchiyama5Makiko Morita6Hitoshi Kawashima7Toshiki Kobayashi8Jun Kunisawa9Graduate School of Veterinary Science, Osaka Metropolitan UniversityLaboratory of Vaccine Materials, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and NutritionLaboratory of Vaccine Materials, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and NutritionLaboratory of Vaccine Materials, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and NutritionLaboratory of Vaccine Materials, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and NutritionLaboratory of Vaccine Materials, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and NutritionLaboratory of Vaccine Materials, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and NutritionLaboratory of Vaccine Materials, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and NutritionLaboratory of Vaccine Materials, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and NutritionLaboratory of Vaccine Materials, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and NutritionAbstract Background The human gut harbors a diverse microbiota that is crucial for maintaining health but also contributes to several diseases. Understanding how microbial communities are assembled and maintained is critical for advancing gut health. Results We identified a unique interaction between the pathobiont Fusobacterium varium and the symbiont Faecalibacterium prausnitzii, both members of the gut microbial community; their interaction is driven by metabolites and direct cell-to-cell contact. Growth of F. varium was inhibited in the presence of F. prausnitzii because of a decrease in pH and an increase in β-hydroxybutyric acid. Conversely, the growth of F. prausnitzii was promoted in the presence of F. varium, likely via direct contact. Conclusions These findings highlight the importance of metabolite-driven interactions and direct contact in shaping gut microbial communities and emphasize the potential of interactions between F. prausnitzii and F. varium in influencing gut health. Video Abstracthttps://doi.org/10.1186/s40168-025-02168-wMicrobial interactionGut ecosystemPathobiontSymbiontFusobacteriumFaecalibacterium |
| spellingShingle | Koji Hosomi Satoko Maruyama Tsubasa Matsuoka Mari Furuta Yoko Tojima Keita Uchiyama Makiko Morita Hitoshi Kawashima Toshiki Kobayashi Jun Kunisawa Metabolite-mediated interactions and direct contact between Fusobacterium varium and Faecalibacterium prausnitzii Microbiome Microbial interaction Gut ecosystem Pathobiont Symbiont Fusobacterium Faecalibacterium |
| title | Metabolite-mediated interactions and direct contact between Fusobacterium varium and Faecalibacterium prausnitzii |
| title_full | Metabolite-mediated interactions and direct contact between Fusobacterium varium and Faecalibacterium prausnitzii |
| title_fullStr | Metabolite-mediated interactions and direct contact between Fusobacterium varium and Faecalibacterium prausnitzii |
| title_full_unstemmed | Metabolite-mediated interactions and direct contact between Fusobacterium varium and Faecalibacterium prausnitzii |
| title_short | Metabolite-mediated interactions and direct contact between Fusobacterium varium and Faecalibacterium prausnitzii |
| title_sort | metabolite mediated interactions and direct contact between fusobacterium varium and faecalibacterium prausnitzii |
| topic | Microbial interaction Gut ecosystem Pathobiont Symbiont Fusobacterium Faecalibacterium |
| url | https://doi.org/10.1186/s40168-025-02168-w |
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