Longitudinal Respiratory Subphenotypes and Differences in Response to Positive End-Expiratory Pressure and Fio2 Ventilation Strategy in COVID-19 ARDSTake-Home Points

Longitudinal Respiratory Subphenotypes and Differences in Response to Positive End-Expiratory Pressure and Fio2 Ventilation Strategy in COVID-19 ARDSTake-Home Points

Background: In patients with ARDS, positive end-expiratory pressure (PEEP) titration remains a challenge and recommendations are not in agreement. In mechanically ventilated patients with COVID-19, subphenotypes based on different respiratory trajectories have been identified, but their heterogeneit...

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Main Authors: Robin L. Goossen, MD, Daan F.L. Filippini, MD, Relin van Vliet, MD, Laura A. Buiteman-Kruizinga, RN, PhD, Markus W. Hollmann, MD, PhD, Sheila N. Myatra, MD, Ary Serpa Neto, MD, PhD, Peter E. Spronk, MD, PhD, Meta C.E. van der Woude, MD, PhD, Marcus J. Schultz, MD, PhD, David M.P. van Meenen, MD, PhD, Frederique Paulus, PhD, Lieuwe D.J. Bos, MD, PhD
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:CHEST Critical Care
Subjects:
COVID-19
critical care
Fio2
PEEP
pneumonia, viral
respiration, artificial
Online Access:http://www.sciencedirect.com/science/article/pii/S2949788425000188
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