Safety and pharmacokinetics of ralinepag, a novel oral prostacyclin receptor agonist

Safety and pharmacokinetics of ralinepag, a novel oral prostacyclin receptor agonist

Background: Ralinepag is an oral, potent, highly selective prostacyclin receptor agonist and is in development for pulmonary arterial hypertension. Ralinepag was formulated as an immediate-release (IR) capsule, later modified to an extended-release (XR) tablet to optimize administration for once-dai...

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Bibliographic Details
Main Authors: Ali Ataya, MD, James C. Coons, PharmD, Natalie Patzlaff, PhD, Meredith Broderick, PharmD, Scott Seaman, PhD, Namita Sood, MD, M. Patricia George, MD, Murali M. Chakinala, MD
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:JHLT Open
Subjects:
Hypertension
Pulmonary/drug therapy
Receptors
Prostaglandin/agonists
Pulmonaryarterial hypertension
Ralinepag
Online Access:http://www.sciencedirect.com/science/article/pii/S2950133425000655
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