Role of the αC-β4 loop in protein kinase structure and dynamics

Role of the αC-β4 loop in protein kinase structure and dynamics

Although the αC-β4 loop is a stable feature of all protein kinases, the importance of this motif as a conserved element of secondary structure, as well as its links to the hydrophobic architecture of the kinase core, has been underappreciated. We first review the motif and then describe how it is li...

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Bibliographic Details
Main Authors: Jian Wu, Nisha A Jonniya, Sophia P Hirakis, Cristina Olivieri, Gianluigi Veglia, Alexandr P Kornev, Susan S Taylor
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
αC-β4 loop
protein kinase A
local spatial pattern
F100A mutant
molecular dynamics simulations
Online Access:https://elifesciences.org/articles/91980
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https://elifesciences.org/articles/91980

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