NMR Data Analysis of Acarbose
Acarbose, an α-glucosidase inhibitor, has been widely used in the treatment of type-II diabetes due to its unique mechanism of action. In this study, comprehensive and accurate 1H and 13C NMR data of acarbose in DMSO-d6, including 1H NMR data of all hydroxyl groups of acarbose as well as 1H and 13C...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Science Press
2025-06-01
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| Series: | Chinese Journal of Magnetic Resonance |
| Subjects: | |
| Online Access: | http://121.43.60.238/bpxzz/article/2025/1000-4556/1000-4556-42-2-184.shtml |
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| Summary: | Acarbose, an α-glucosidase inhibitor, has been widely used in the treatment of type-II diabetes due to its unique mechanism of action. In this study, comprehensive and accurate 1H and 13C NMR data of acarbose in DMSO-d6, including 1H NMR data of all hydroxyl groups of acarbose as well as 1H and 13C NMR data of the dual signal of C-ring α and β, were reported for the first time. The assignment of 1H and 13C NMR data was conducted using DEPT-135, 1H-1H COSY, 1H-13C HSQC, and 1H-13C HMBC techniques. The molecular structure of acarbose was confirmed, providing a reliable data basis for the safety and quality control of acarbose drugs. |
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| ISSN: | 1000-4556 |