Comparative Evaluation of Salivary Ferritin Levels as a Predictor Inflammatory Biomarker Before and After Non Surgical Periodontal Therapy- An Interventional Study
Background: Ferritin plays a crucial role in the host immune response, with elevated serum ferritin levels established in various chronic inflammation-related diseases, including periodontitis. This study aimed to evaluate the efficacy of nonsurgical periodontal treatment on salivary ferritin levels...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_759_24 |
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| author | Saurabh Tembhurne Sachin K. Malagi Dennis V. Abraham Kshitibhushan S. Pandaw Arundhuti Mahato Priyal Agrawal |
| author_facet | Saurabh Tembhurne Sachin K. Malagi Dennis V. Abraham Kshitibhushan S. Pandaw Arundhuti Mahato Priyal Agrawal |
| author_sort | Saurabh Tembhurne |
| collection | DOAJ |
| description | Background:
Ferritin plays a crucial role in the host immune response, with elevated serum ferritin levels established in various chronic inflammation-related diseases, including periodontitis. This study aimed to evaluate the efficacy of nonsurgical periodontal treatment on salivary ferritin levels in periodontally healthy and chronic periodontitis patients.
Materials and Methods:
Fifty patients were selected and divided into two groups: a control group of healthy individuals and an experimental group of chronic periodontitis patients. Salivary samples were collected using the drooling method to assess ferritin levels. The experimental group underwent nonsurgical periodontal therapy, with clinical parameters [plaque index (PI), gingival index (GI), oral hygiene index-simplified (OHIS), bleeding point index (BPI), probing pocket depth (PPD), and clinical attachment level (CAL)] recorded before and one month after therapy. Salivary samples were analyzed using CLIA, and statistical analysis was performed.
Results:
The control group showed significantly lower ferritin levels compared to the periodontitis group. Post-therapy, the periodontitis group exhibited significant improvements in both clinical parameters and ferritin levels.
Conclusion:
Salivary ferritin levels effectively predict periodontal disease and the impact of periodontal therapy, demonstrating its potential as a valuable biomarker for diagnosing and monitoring periodontal health. |
| format | Article |
| id | doaj-art-d922b39481fa45abaf15ee9fd7a3fbc0 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-d922b39481fa45abaf15ee9fd7a3fbc02025-01-12T14:14:10ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S3266S326810.4103/jpbs.jpbs_759_24Comparative Evaluation of Salivary Ferritin Levels as a Predictor Inflammatory Biomarker Before and After Non Surgical Periodontal Therapy- An Interventional StudySaurabh TembhurneSachin K. MalagiDennis V. AbrahamKshitibhushan S. PandawArundhuti MahatoPriyal AgrawalBackground: Ferritin plays a crucial role in the host immune response, with elevated serum ferritin levels established in various chronic inflammation-related diseases, including periodontitis. This study aimed to evaluate the efficacy of nonsurgical periodontal treatment on salivary ferritin levels in periodontally healthy and chronic periodontitis patients. Materials and Methods: Fifty patients were selected and divided into two groups: a control group of healthy individuals and an experimental group of chronic periodontitis patients. Salivary samples were collected using the drooling method to assess ferritin levels. The experimental group underwent nonsurgical periodontal therapy, with clinical parameters [plaque index (PI), gingival index (GI), oral hygiene index-simplified (OHIS), bleeding point index (BPI), probing pocket depth (PPD), and clinical attachment level (CAL)] recorded before and one month after therapy. Salivary samples were analyzed using CLIA, and statistical analysis was performed. Results: The control group showed significantly lower ferritin levels compared to the periodontitis group. Post-therapy, the periodontitis group exhibited significant improvements in both clinical parameters and ferritin levels. Conclusion: Salivary ferritin levels effectively predict periodontal disease and the impact of periodontal therapy, demonstrating its potential as a valuable biomarker for diagnosing and monitoring periodontal health.https://journals.lww.com/10.4103/jpbs.jpbs_759_24biomarkerperiodontal therapysalivary ferritin |
| spellingShingle | Saurabh Tembhurne Sachin K. Malagi Dennis V. Abraham Kshitibhushan S. Pandaw Arundhuti Mahato Priyal Agrawal Comparative Evaluation of Salivary Ferritin Levels as a Predictor Inflammatory Biomarker Before and After Non Surgical Periodontal Therapy- An Interventional Study Journal of Pharmacy and Bioallied Sciences biomarker periodontal therapy salivary ferritin |
| title | Comparative Evaluation of Salivary Ferritin Levels as a Predictor Inflammatory Biomarker Before and After Non Surgical Periodontal Therapy- An Interventional Study |
| title_full | Comparative Evaluation of Salivary Ferritin Levels as a Predictor Inflammatory Biomarker Before and After Non Surgical Periodontal Therapy- An Interventional Study |
| title_fullStr | Comparative Evaluation of Salivary Ferritin Levels as a Predictor Inflammatory Biomarker Before and After Non Surgical Periodontal Therapy- An Interventional Study |
| title_full_unstemmed | Comparative Evaluation of Salivary Ferritin Levels as a Predictor Inflammatory Biomarker Before and After Non Surgical Periodontal Therapy- An Interventional Study |
| title_short | Comparative Evaluation of Salivary Ferritin Levels as a Predictor Inflammatory Biomarker Before and After Non Surgical Periodontal Therapy- An Interventional Study |
| title_sort | comparative evaluation of salivary ferritin levels as a predictor inflammatory biomarker before and after non surgical periodontal therapy an interventional study |
| topic | biomarker periodontal therapy salivary ferritin |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_759_24 |
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