LM-Merger: a workflow for merging logical models with an application to gene regulatory network models

LM-Merger: a workflow for merging logical models with an application to gene regulatory network models

Abstract Background Gene regulatory network (GRN) models provide mechanistic understanding of genetic interactions that regulate gene expression and, consequently, influence cellular behavior. Dysregulated gene expression plays a critical role in disease progression and treatment response, making GR...

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Bibliographic Details
Main Authors: Luna Xingyu Li, Boris Aguilar, John Gennari, Guangrong Qin
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Bioinformatics
Subjects:
Gene regulatory networks
Logical models
Model integration
Acute myeloid leukemia
Systems biology
Online Access:https://doi.org/10.1186/s12859-025-06212-2
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https://doi.org/10.1186/s12859-025-06212-2

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