Recurrent integration of domestic cat hepatitis B virus DNA near feline CCNE1 supports an oncogenic role in hepatocellular carcinoma in cats

Recurrent integration of domestic cat hepatitis B virus DNA near feline CCNE1 supports an oncogenic role in hepatocellular carcinoma in cats

Hepatitis B virus (HBV) is the major cause of hepatocellular carcinoma (HCC) in humans. Domestic cat hepatitis B virus (DCHBV) naturally infects cats worldwide, but the oncogenic potential of this hepadnavirus is unclear. We investigated whether DCHBV contributes to feline HCC. Feline liver biopsies...

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Bibliographic Details
Main Authors: João P. Cavasin, Min-Chun Chen, Harout Ajoyan, Melanie J. Dobromylskyj, Wei-Hsiang Huang, Mason Jager, Kate Van Brussel, Rebecca Rockett, Omid Nekouei, Penny Watson, Jason Bestwick, Yan Ru Choi, Jonathan A. Lidbury, John M. Cullen, Edward Holmes, Jörg M. Steiner, Thomas Tu, Julia A. Beatty
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Tumour Virus Research
Subjects:
Hepatocarcinogenesis
Hepadnavirus
Oncogenic virus
Companion animal
Feline
Insertional mutagenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2666679025000126
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