Navigating the complex role of senescence in liver disease
Abstract. Cellular senescence, an irreversible state of cell cycle arrest characterized by phenotypic changes and a specific secretory profile, plays a dual role in liver health and disease. Under physiological conditions, senescence aids organ repair and regeneration, but its accumulation due to ag...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2024-12-01
|
| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000003439 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841550803700023296 |
|---|---|
| author | Qiuting Li Lin Wang Yuanyuan Ji |
| author_facet | Qiuting Li Lin Wang Yuanyuan Ji |
| author_sort | Qiuting Li |
| collection | DOAJ |
| description | Abstract. Cellular senescence, an irreversible state of cell cycle arrest characterized by phenotypic changes and a specific secretory profile, plays a dual role in liver health and disease. Under physiological conditions, senescence aids organ repair and regeneration, but its accumulation due to aging or pathological stress significantly contributes to chronic liver diseases, including alcoholic liver disease, metabolic dysfunction-associated steatohepatitis, liver fibrosis, and hepatocellular carcinoma. Senescence is identified by a range of cellular and molecular changes, such as morphological alterations, expression of cell cycle inhibitors, senescence-associated β-galactosidase activity, and nuclear membrane changes. The onset of senescence in organ cells can affect the entire organism, primarily through the senescence-associated secretory phenotype, which has autocrine, paracrine, and endocrine effects on tissue microenvironments. The objective of this review is to offer a contemporary overview of the pathophysiological events involving hepatic senescent cells and to elucidate their role in the onset and progression of liver diseases, particularly through mechanisms like telomere shortening, genomic and mitochondrial DNA damage, and inflammation. Additionally, this review discusses the emerging senolytic therapies aimed at targeting senescent cells to delay or mitigate liver disease progression. The therapeutic potential of these interventions, alongside their safety and effectiveness, highlights the need for further research to refine these approaches and address unresolved problems in the field of hepatic cellular senescence. |
| format | Article |
| id | doaj-art-d8f79b61f9a44c978171bbde9e197f49 |
| institution | Kabale University |
| issn | 0366-6999 2542-5641 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj-art-d8f79b61f9a44c978171bbde9e197f492025-01-10T01:10:24ZengWolters KluwerChinese Medical Journal0366-69992542-56412024-12-01137243061307210.1097/CM9.0000000000003439202412200-00008Navigating the complex role of senescence in liver diseaseQiuting Li0Lin Wang1Yuanyuan JiDepartment of Hepatobiliary Surgery, Xi-Jing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi 710032, ChinaDepartment of Hepatobiliary Surgery, Xi-Jing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi 710032, ChinaAbstract. Cellular senescence, an irreversible state of cell cycle arrest characterized by phenotypic changes and a specific secretory profile, plays a dual role in liver health and disease. Under physiological conditions, senescence aids organ repair and regeneration, but its accumulation due to aging or pathological stress significantly contributes to chronic liver diseases, including alcoholic liver disease, metabolic dysfunction-associated steatohepatitis, liver fibrosis, and hepatocellular carcinoma. Senescence is identified by a range of cellular and molecular changes, such as morphological alterations, expression of cell cycle inhibitors, senescence-associated β-galactosidase activity, and nuclear membrane changes. The onset of senescence in organ cells can affect the entire organism, primarily through the senescence-associated secretory phenotype, which has autocrine, paracrine, and endocrine effects on tissue microenvironments. The objective of this review is to offer a contemporary overview of the pathophysiological events involving hepatic senescent cells and to elucidate their role in the onset and progression of liver diseases, particularly through mechanisms like telomere shortening, genomic and mitochondrial DNA damage, and inflammation. Additionally, this review discusses the emerging senolytic therapies aimed at targeting senescent cells to delay or mitigate liver disease progression. The therapeutic potential of these interventions, alongside their safety and effectiveness, highlights the need for further research to refine these approaches and address unresolved problems in the field of hepatic cellular senescence.http://journals.lww.com/10.1097/CM9.0000000000003439 |
| spellingShingle | Qiuting Li Lin Wang Yuanyuan Ji Navigating the complex role of senescence in liver disease Chinese Medical Journal |
| title | Navigating the complex role of senescence in liver disease |
| title_full | Navigating the complex role of senescence in liver disease |
| title_fullStr | Navigating the complex role of senescence in liver disease |
| title_full_unstemmed | Navigating the complex role of senescence in liver disease |
| title_short | Navigating the complex role of senescence in liver disease |
| title_sort | navigating the complex role of senescence in liver disease |
| url | http://journals.lww.com/10.1097/CM9.0000000000003439 |
| work_keys_str_mv | AT qiutingli navigatingthecomplexroleofsenescenceinliverdisease AT linwang navigatingthecomplexroleofsenescenceinliverdisease AT yuanyuanji navigatingthecomplexroleofsenescenceinliverdisease |