Rapid and supersensitive allele detection of Plasmodium falciparum chloroquine resistance via a Pyrococcus furiosus argonaute-triggered dual-signal biosensing platform

Rapid and supersensitive allele detection of Plasmodium falciparum chloroquine resistance via a Pyrococcus furiosus argonaute-triggered dual-signal biosensing platform

Abstract Background Malaria remains a serious public health problem worldwide, particularly in Africa. Resistance to antimalarial drugs is an essential issue for malaria control and elimination. Currently, polymerase chain reaction (PCR) combined with Sanger sequencing is regarded as the gold standa...

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Main Authors: Liying Chen, Wencheng Chen, Huagui Wei, Wenai Lin, Cheng Zhang, Hongfei Hu, Chunfang Wang, Jiangtao Chen, Xueyan Liang, Daiqian Zhu, Junli Wang, Zongyun Lin, Yuxia Wei, Jian Li, Min Lin
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Parasites & Vectors
Subjects:
Pyrococcus furiosus argonaute (PfAgo)
Recombinase polymerase amplification (RPA)
Plasmodium falciparum chloroquine resistance transporter (Pfcrt)
Genotyping
Haplotype detection
Point-of-care testing (POCT)
Online Access:https://doi.org/10.1186/s13071-024-06575-0
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https://doi.org/10.1186/s13071-024-06575-0

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