Efficacy and Safety of Nebulized Sodium Bicarbonate in Adults with COVID-19 (SODIC): A Randomized, Single-Center, Double-Blinded, Controlled Trial

Efficacy and Safety of Nebulized Sodium Bicarbonate in Adults with COVID-19 (SODIC): A Randomized, Single-Center, Double-Blinded, Controlled Trial

Background: Entry of severe acute respiratory syndrome coronavirus 2 into a host cell is pH-dependent. Hence, intracellular alkalinization by nebulized sodium bicarbonate could elevate endosomal pH and then block viral entry into the host cells. Objective: To study the efficacy of nebulized sodium b...

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Main Authors: Mohammad Khairy El-Badrawy, MD, Rehab Ahmad Elmorsey, MD, Mahmoud Mostafa Elhosiny, MD, Mohammed Shehta, MD, Tamer Ali El-Hadidy, MD, Ibrahim El-Said Abdelwahab, MD, Adel El-Badrawy, MD, Ahmed A. Shokeir, MD
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Therapeutic Research
Subjects:
Alkalinization
COVID‑19
Endosomal pH
Pneumonia
Sodium bicarbonate
Online Access:http://www.sciencedirect.com/science/article/pii/S0011393X25000268
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