A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics

Abstract Physiological changes during pregnancy support foetal growth, including adaptations in pancreatic islets to maintain glucose homeostasis. We investigate these adaptations using rare, high-quality pancreatic tissue from pregnant human donors and matched controls. We profile islets from pregn...

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Bibliographic Details
Main Authors: Faheem Seedat, Katie Holden, Simon Davis, Roman Fischer, James Bancroft, Edward Drydale, Neva Kandzija, John A. Todd, Manu Vatish, M. Irina Stefana
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61852-5
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