Dual rectification of metabolism abnormality in pancreatic cancer by a programmed nanomedicine

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal malignancy characterized by dysregulated energy and stromal metabolism. It is strongly supported by activated pancreatic stellate cells (PSC) which drive excessive desmoplasia and tumor growth via metabolic crosstalk....

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Bibliographic Details
Main Authors: Bowen Wu, Zhiqin Wang, Jingyuan Liu, Naishi Li, Xudong Wang, HaoChen Bai, Chunling Wang, Jian Shi, Saiyang Zhang, Jian Song, Yiye Li, Guangjun Nie
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54963-y
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