Heterozygous GAA knockout is nonconsequential on metabolism and the spatial liver transcriptome in high‐fat diet‐induced obese and prediabetic mice
Abstract Glycophagy is the autophagic degradation of glycogen by the enzyme acid alpha‐glucosidase (GAA). Although GAA inhibitors improve metabolic health by inhibiting GAA in the intestine, it is not clear if GAA inhibition in peripheral tissues such as the liver is metabolically beneficial. This s...
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| Main Authors: | Cameron P. McCall, Melina C. Mancini, Jaroslaw Staszkiewicz, Douglas G. Mashek, Timothy D. Heden |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-03-01
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| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.70276 |
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