Heterozygous GAA knockout is nonconsequential on metabolism and the spatial liver transcriptome in high‐fat diet‐induced obese and prediabetic mice

Heterozygous GAA knockout is nonconsequential on metabolism and the spatial liver transcriptome in high‐fat diet‐induced obese and prediabetic mice

Abstract Glycophagy is the autophagic degradation of glycogen by the enzyme acid alpha‐glucosidase (GAA). Although GAA inhibitors improve metabolic health by inhibiting GAA in the intestine, it is not clear if GAA inhibition in peripheral tissues such as the liver is metabolically beneficial. This s...

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Bibliographic Details
Main Authors: Cameron P. McCall, Melina C. Mancini, Jaroslaw Staszkiewicz, Douglas G. Mashek, Timothy D. Heden
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Physiological Reports
Subjects:
glycogen autophagy
glycophagy
liver
metabolism
prediabetes
Online Access:https://doi.org/10.14814/phy2.70276
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https://doi.org/10.14814/phy2.70276

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