Nootkatone Alleviates Type 2 Diabetes in db/db Mice Through AMPK Activation and ERK Inhibition: An Integrated In Vitro and In Vivo Study

Nootkatone Alleviates Type 2 Diabetes in db/db Mice Through AMPK Activation and ERK Inhibition: An Integrated In Vitro and In Vivo Study

Type 2 diabetes mellitus (T2DM) is a common chronic metabolic disorder that imposes a substantial healthcare burden globally. Recent advances highlight the potential of natural products in ameliorating T2DM. In this study, we investigated the therapeutic efficacy of nootkatone (Nok), a natural sesqu...

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Bibliographic Details
Main Authors: Yingjie Li, Linlin Zheng, Mimi Chen, Ruodi Li, Yansu Yu, Lu Qiao, Jialu Liu, Xiaopo Zhang, Yong Zhang, Yuxin Zhang, Wei Zheng
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
nootkatone
diabetes
liver
pancreatic
network pharmacology
db/db mice
Online Access:https://www.mdpi.com/1420-3049/30/10/2111
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