A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes

Abstract Blood glucose fluctuation leads to poor bone defect repair in patients with type 2 diabetes (T2DM). Strategies to safely and efficiently improve the bone regeneration disorder caused by blood glucose fluctuation are still a challenge. Neutral sphingophospholipase 2 (Smpd3) is downregulated...

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Bibliographic Details
Main Authors: Lingxiao Wang, Haoqing Yang, Chen Zhang, Yue Zhang, Yilin He, Yang Liu, Pan Ma, Jun Li, Zhipeng Fan
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:International Journal of Oral Science
Online Access:https://doi.org/10.1038/s41368-024-00328-6
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