Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models

Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models

Abstract Whole‐genome sequencing (WGS) of circulating tumour DNA (ctDNA) is now a clinically important biomarker for predicting therapy response, disease burden and disease progression. However, the translation of ctDNA monitoring into vital preclinical PDX models has not been possible owing to low...

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Main Authors: Carolin M Sauer, Katrin Heider, Jelena Belic, Samantha E Boyle, James A Hall, Dominique‐Laurent Couturier, Angela An, Aadhitthya Vijayaraghavan, Marika AV Reinius, Karen Hosking, Maria Vias, Nitzan Rosenfeld, James D Brenton
Format: Article
Language:English
Published: Springer Nature 2022-06-01
Series:EMBO Molecular Medicine
Subjects:
circulating tumour DNA
copy number aberrations
liquid biopsies
PDX models
preclinical treatment study
Online Access:https://doi.org/10.15252/emmm.202215729
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https://doi.org/10.15252/emmm.202215729

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