Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma

Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma

BackgroundStudies have shown that tumor cell amino acid metabolism is closely associated with lung adenocarcinoma (LUAD) development and progression. However, the comprehensive multi-omics features and clinical impact of the expression of genes associated with amino acid metabolism in the LUAD tumor...

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Main Authors: Huihui Xiang, Rika Kasajima, Koichi Azuma, Tomoyuki Tagami, Asami Hagiwara, Yoshiro Nakahara, Haruhiro Saito, Yuka Igarashi, Feifei Wei, Tatsuma Ban, Mitsuyo Yoshihara, Yoshiyasu Nakamura, Shinya Sato, Shiro Koizume, Tomohiko Tamura, Tetsuro Sasada, Yohei Miyagi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
prognostic gene signature
amino acid metabolism pathway
lung adenocarcinoma
multi-omics analysis
TP53 mutation
plasma-free α-aminobutyric acid
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1361992/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1361992/full

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