Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor

Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor

The gut microbiota-brain axis has been associated with the pathogenesis of numerous disorders, but the mechanism(s) underlying these links are generally poorly understood. Accumulating evidence indicates the involvement of gut microbe-derived metabolites. Circulating levels of the gut microbe/host c...

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Main Authors: Sita N. Shah, Tobias B-A. Knausenberger, Matthew G. Pontifex, Emily Connell, Gwénaëlle Le Gall, Tom A.J. Hardy, David W. Randall, Kieran McCafferty, Muhammad M. Yaqoob, Egle Solito, Michael Müller, Andrew V. Stachulski, Robert C. Glen, David Vauzour, Lesley Hoyles, Simon McArthur
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Gut Microbes
Subjects:
Blood-brain barrier
p-cresol sulfate
cerebrovascular disease
chronic kidney disease
gut microbiota
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2024.2431651
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https://www.tandfonline.com/doi/10.1080/19490976.2024.2431651

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