Intranasal Mitochondrial Transplantation Restores Mitochondrial Function and Modulates Glial–Neuronal Interactions in a Genetic Parkinson’s Disease Model of <i>UQCRC1</i> Mutation

Intranasal Mitochondrial Transplantation Restores Mitochondrial Function and Modulates Glial–Neuronal Interactions in a Genetic Parkinson’s Disease Model of <i>UQCRC1</i> Mutation

The intranasal delivery of exogenous mitochondria is a potential therapy for Parkinson’s disease (PD). The regulatory mechanisms and effectiveness in genetic models remains uncertain, as well as the impact of modulating the mitochondrial permeability transition pore (mPTP) in grafts. Utilizing <i...

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Bibliographic Details
Main Authors: Jui-Chih Chang, Chin-Hsien Lin, Cheng-Yi Yeh, Mei-Fang Cheng, Yi-Chieh Chen, Chi-Han Wu, Hui-Ju Chang, Chin-San Liu
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
mitochondrial transplantation
intranasal delivery
Parkinson’s disease
<i>UQCRC1</i> mutation (p.Tyr314Ser) knock-in mice
cyclosporine A
mitochondrial function
Online Access:https://www.mdpi.com/2073-4409/14/15/1148
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