Single-cell transcriptomic profiling reveals a novel signature of necrotizing granulomatous lesions in the lungs of Mycobacterium tuberculosis-infected C3HeB/FeJ mice

Single-cell transcriptomic profiling reveals a novel signature of necrotizing granulomatous lesions in the lungs of Mycobacterium tuberculosis-infected C3HeB/FeJ mice

Tuberculosis (TB) pathology involves complex immune responses within granulomatous lesions. Using single-cell RNA sequencing, we characterized the cellular compositions of necrotizing granulomatous lesions that developed in the lungs of Mycobacterium tuberculosis-infected C3HeB/FeJ mice. We identifi...

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Bibliographic Details
Main Authors: Shintaro Seto, Shiho Omori, Hajime Nakamura, Minako Hijikata, Naoto Keicho
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
Mycobacterium tuberculosis
C3HeB/FeJ TB model
necrotizing granuloma
foamy macrophage
scRNA-seq
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1624072/full
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