Evaluation of diverse polygenic risk score models for lung cancer in a small-scale Chinese cohort

Evaluation of diverse polygenic risk score models for lung cancer in a small-scale Chinese cohort

IntroductionLung cancer is a leading cause of cancer-related mortality globally, with distinct epidemiological and genetic patterns in East Asian populations. However, most polygenic risk score (PRS) models have been developed using European-ancestry cohorts, raising concerns about their applicabili...

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Bibliographic Details
Main Authors: Min Gao, Qiwen Zheng, Yue Jiang, Xiao Chang, Xin Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Genetics
Subjects:
polygenic risk score
lung cancer
PRS-CS
Chinese population
genome-wide association study
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1646997/full
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https://www.frontiersin.org/articles/10.3389/fgene.2025.1646997/full

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