Integrated multiomics signatures to optimize the accurate diagnosis of lung cancer

Integrated multiomics signatures to optimize the accurate diagnosis of lung cancer

Abstract Diagnosing lung cancer from indeterminate pulmonary nodules (IPLs) remains challenging. In this multi-institutional study involving 2032 participants with IPLs, we integrate the clinical, radiomic with circulating cell-free DNA fragmentomic features in 5-methylcytosine (5mC)-enriched region...

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Main Authors: Mengmeng Zhao, Gang Xue, Bingxi He, Jiajun Deng, Tingting Wang, Yifan Zhong, Shenghui Li, Yang Wang, Yiming He, Tao Chen, Jun Zhang, Ziyue Yan, Xinlei Hu, Liuning Guo, Wendong Qu, Yongxiang Song, Minglei Yang, Guofang Zhao, Bentong Yu, Minjie Ma, Lunxu Liu, Xiwen Sun, Yunlang She, Dan Xie, Deping Zhao, Chang Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55594-z
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https://doi.org/10.1038/s41467-024-55594-z

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