The association between primary frozen shoulder and serum lipids may be overestimated: evidence based on retrospective observational studies and Mendelian randomization
BackgroundPrevious studies have shown that dyslipidemia is significantly associated with primary frozen shoulder and may be a risk factor for the development of primary frozen shoulder. However, these findings may be biased by a number of confounding factors. We investigated the association between...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1363018/full |
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| author | Yongchao Zhang Wenhao Fan Yichang Wang Tengjing Dong Deding Liu Yiming Shao |
| author_facet | Yongchao Zhang Wenhao Fan Yichang Wang Tengjing Dong Deding Liu Yiming Shao |
| author_sort | Yongchao Zhang |
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| description | BackgroundPrevious studies have shown that dyslipidemia is significantly associated with primary frozen shoulder and may be a risk factor for the development of primary frozen shoulder. However, these findings may be biased by a number of confounding factors. We investigated the association between serum lipids and primary frozen shoulder by retrospective analysis and two-sample Mendelian randomization (MR) methods.MethodsThis retrospective observational study included 284 patients with primary frozen shoulder diagnosed from October 2020 to October 2023 at four centers as the experimental group. Patients with diabetes and thyroid dysfunction were excluded. The control group consisted of age- and sex-matched people who underwent a health checkup. We compared total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) between the two groups. Genetic variants for the serum lipids and frozen shoulder were then extracted from large-scale genome-wide association studies. Causal effects were assessed using Inverse variance weighting (IVW), Weighted median, MR-Egger, simple and weighted models in MR analysis.ResultsThe analysis showed that after excluding patients with diabetes and thyroid dysfunction, the serum lipids (TC, TG, HDL, and LDL) in the primary frozen shoulder group were no different from those of normal individuals. None of the MR methods found significant causal evidence between them.ConclusionsDyslipidemia in patients with primary frozen shoulder may be influenced by confounding factors such as diabetes and thyroid dysfunction. These findings deepen our understanding of primary frozen shoulder risk factors. |
| format | Article |
| id | doaj-art-d61d906217874b27a5d7001113120050 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-d61d906217874b27a5d70011131200502025-01-15T05:11:08ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.13630181363018The association between primary frozen shoulder and serum lipids may be overestimated: evidence based on retrospective observational studies and Mendelian randomizationYongchao Zhang0Wenhao Fan1Yichang Wang2Tengjing Dong3Deding Liu4Yiming Shao5Department of Joint and Sports Injuries, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, ChinaDepartment of Foot and Ankle Surgery, Zhengzhou Orthopedic Hospital Affiliated to Henan University, Zhengzhou, ChinaDepartment of Pain, Shunde Hospital of Southern Medical University, Foshan, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Joint and Sports Injuries, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, ChinaDepartment of Trauma Surgery, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, ChinaBackgroundPrevious studies have shown that dyslipidemia is significantly associated with primary frozen shoulder and may be a risk factor for the development of primary frozen shoulder. However, these findings may be biased by a number of confounding factors. We investigated the association between serum lipids and primary frozen shoulder by retrospective analysis and two-sample Mendelian randomization (MR) methods.MethodsThis retrospective observational study included 284 patients with primary frozen shoulder diagnosed from October 2020 to October 2023 at four centers as the experimental group. Patients with diabetes and thyroid dysfunction were excluded. The control group consisted of age- and sex-matched people who underwent a health checkup. We compared total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) between the two groups. Genetic variants for the serum lipids and frozen shoulder were then extracted from large-scale genome-wide association studies. Causal effects were assessed using Inverse variance weighting (IVW), Weighted median, MR-Egger, simple and weighted models in MR analysis.ResultsThe analysis showed that after excluding patients with diabetes and thyroid dysfunction, the serum lipids (TC, TG, HDL, and LDL) in the primary frozen shoulder group were no different from those of normal individuals. None of the MR methods found significant causal evidence between them.ConclusionsDyslipidemia in patients with primary frozen shoulder may be influenced by confounding factors such as diabetes and thyroid dysfunction. These findings deepen our understanding of primary frozen shoulder risk factors.https://www.frontiersin.org/articles/10.3389/fendo.2024.1363018/fullprimary frozen shoulderserum lipidMendelian randomizationcorrelationcausality |
| spellingShingle | Yongchao Zhang Wenhao Fan Yichang Wang Tengjing Dong Deding Liu Yiming Shao The association between primary frozen shoulder and serum lipids may be overestimated: evidence based on retrospective observational studies and Mendelian randomization Frontiers in Endocrinology primary frozen shoulder serum lipid Mendelian randomization correlation causality |
| title | The association between primary frozen shoulder and serum lipids may be overestimated: evidence based on retrospective observational studies and Mendelian randomization |
| title_full | The association between primary frozen shoulder and serum lipids may be overestimated: evidence based on retrospective observational studies and Mendelian randomization |
| title_fullStr | The association between primary frozen shoulder and serum lipids may be overestimated: evidence based on retrospective observational studies and Mendelian randomization |
| title_full_unstemmed | The association between primary frozen shoulder and serum lipids may be overestimated: evidence based on retrospective observational studies and Mendelian randomization |
| title_short | The association between primary frozen shoulder and serum lipids may be overestimated: evidence based on retrospective observational studies and Mendelian randomization |
| title_sort | association between primary frozen shoulder and serum lipids may be overestimated evidence based on retrospective observational studies and mendelian randomization |
| topic | primary frozen shoulder serum lipid Mendelian randomization correlation causality |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1363018/full |
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