High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China
Abstract Food workers have frequent contact with unprocessed foods, but their carriage of Salmonella and potential influence on public health have not been comprehensively assessed. We investigated Salmonella carriage among food workers compared with non-food workers based on occupational health scr...
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Nature Portfolio
2024-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54405-9 |
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| author | Xin Lu Ming Luo Mengyu Wang Zhemin Zhou Jialiang Xu Zhenpeng Li Yao Peng Yuan Zhang Fangyu Ding Dong Jiang Changyu Zhou Liya Yang Wenxuan Zhao Tian Ma Bo Pang Meiying Yan Yongning Wu Yannong Wu Biao Kan |
| author_facet | Xin Lu Ming Luo Mengyu Wang Zhemin Zhou Jialiang Xu Zhenpeng Li Yao Peng Yuan Zhang Fangyu Ding Dong Jiang Changyu Zhou Liya Yang Wenxuan Zhao Tian Ma Bo Pang Meiying Yan Yongning Wu Yannong Wu Biao Kan |
| author_sort | Xin Lu |
| collection | DOAJ |
| description | Abstract Food workers have frequent contact with unprocessed foods, but their carriage of Salmonella and potential influence on public health have not been comprehensively assessed. We investigated Salmonella carriage among food workers compared with non-food workers based on occupational health screening of 260,315 asymptomatic workers over an 8-year surveillance period in Yulin, China. We confirmed that healthy carriers serve as natural reservoirs for Salmonella, with higher carriage rates in food workers than non-food workers. The isolates from food workers also exhibited greater serovar diversity and likely higher levels of antimicrobial resistance than those from non-food workers. Factors such as meteorological, social, and hygiene factors potentially influenced the carriage rate. Genomic analysis revealed a consistent increase in antimicrobial resistance genes among Salmonella isolates over the study period, with the majority of these antimicrobial resistance genes located on plasmids. Additionally, we identified numerous closely related bacterial clusters, which might reflect clusters of hidden local foodborne infections. This study underscores the elevated risk posed by food workers in the persistence and dissemination of Salmonella as vectors/fomites. Enhanced monitoring and targeted interventions in this group may reduce the dissemination of pathogens and antimicrobial resistance genes. |
| format | Article |
| id | doaj-art-d60ebfc8f6364327aca4b6c88f8a8b3c |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-d60ebfc8f6364327aca4b6c88f8a8b3c2024-12-01T12:33:51ZengNature PortfolioNature Communications2041-17232024-11-0115111110.1038/s41467-024-54405-9High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, ChinaXin Lu0Ming Luo1Mengyu Wang2Zhemin Zhou3Jialiang Xu4Zhenpeng Li5Yao Peng6Yuan Zhang7Fangyu Ding8Dong Jiang9Changyu Zhou10Liya Yang11Wenxuan Zhao12Tian Ma13Bo Pang14Meiying Yan15Yongning Wu16Yannong Wu17Biao Kan18National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and PreventionYulin Center for Disease Control and PreventionNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and PreventionNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and PreventionSchool of Light Industry Science and Engineering, Beijing Technology and Business UniversityNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and PreventionNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and PreventionNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and PreventionInstitute of Geographic Sciences and Natural Resources Research, Chinese Academy of SciencesInstitute of Geographic Sciences and Natural Resources Research, Chinese Academy of SciencesYulin Center for Disease Control and PreventionNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and PreventionNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and PreventionInstitute of Geographic Sciences and Natural Resources Research, Chinese Academy of SciencesNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and PreventionNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and PreventionNHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk AssessmentYulin Center for Disease Control and PreventionNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and PreventionAbstract Food workers have frequent contact with unprocessed foods, but their carriage of Salmonella and potential influence on public health have not been comprehensively assessed. We investigated Salmonella carriage among food workers compared with non-food workers based on occupational health screening of 260,315 asymptomatic workers over an 8-year surveillance period in Yulin, China. We confirmed that healthy carriers serve as natural reservoirs for Salmonella, with higher carriage rates in food workers than non-food workers. The isolates from food workers also exhibited greater serovar diversity and likely higher levels of antimicrobial resistance than those from non-food workers. Factors such as meteorological, social, and hygiene factors potentially influenced the carriage rate. Genomic analysis revealed a consistent increase in antimicrobial resistance genes among Salmonella isolates over the study period, with the majority of these antimicrobial resistance genes located on plasmids. Additionally, we identified numerous closely related bacterial clusters, which might reflect clusters of hidden local foodborne infections. This study underscores the elevated risk posed by food workers in the persistence and dissemination of Salmonella as vectors/fomites. Enhanced monitoring and targeted interventions in this group may reduce the dissemination of pathogens and antimicrobial resistance genes.https://doi.org/10.1038/s41467-024-54405-9 |
| spellingShingle | Xin Lu Ming Luo Mengyu Wang Zhemin Zhou Jialiang Xu Zhenpeng Li Yao Peng Yuan Zhang Fangyu Ding Dong Jiang Changyu Zhou Liya Yang Wenxuan Zhao Tian Ma Bo Pang Meiying Yan Yongning Wu Yannong Wu Biao Kan High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China Nature Communications |
| title | High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China |
| title_full | High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China |
| title_fullStr | High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China |
| title_full_unstemmed | High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China |
| title_short | High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China |
| title_sort | high carriage and possible hidden spread of multidrug resistant salmonella among asymptomatic workers in yulin china |
| url | https://doi.org/10.1038/s41467-024-54405-9 |
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