Micellized Naringenin Augments Hemodynamics After Myocardial Infarction by Suppressing Tubulin Detyrosination

Micellized Naringenin Augments Hemodynamics After Myocardial Infarction by Suppressing Tubulin Detyrosination

Impaired contractility after myocardial infarction (MI) causes cardiogenic shock. MARK4 activity impairs contractility post-MI by increasing α-tubulin detyrosination. We assessed the impact of naringenin, a small-molecule MARK4 inhibitor, on contractility post-MI. Naringenin (Nar) was encapsulated i...

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Main Authors:	Noah Weingarten, Amit Iyengar, Jessica Dominic, Danika Meldrum, Andrew Belec, Sara Guevara-Plunkett, Rachel Wilson, Joyce Ho, Mrinal Patel, Chaitanya Karimanasseri, Ahmad Amirshaghaghi, Daphne Nie, Benjamin W. Lee, Deborah M. Eaton, Kenneth B. Margulies, Zhiliang Cheng, Andrew Tsourkas, Pavan Atluri
Format:	Article
Language:	English
Published:	MDPI AG 2024-12-01
Series:	Applied Sciences
Subjects:	naringenin MARK4 microtubule inotrope myocardial infarction
Online Access:	https://www.mdpi.com/2076-3417/14/24/11936
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