Endogenous oligomer formation underlies DVL2 condensates and promotes Wnt/β-catenin signaling

Endogenous oligomer formation underlies DVL2 condensates and promotes Wnt/β-catenin signaling

Activation of the Wnt/β-catenin pathway crucially depends on the polymerization of dishevelled 2 (DVL2) into biomolecular condensates. However, given the low affinity of known DVL2 self-interaction sites and its low cellular concentration, it is unclear how polymers can form. Here, we detect oligome...

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Bibliographic Details
Main Authors: Senem Ntourmas, Martin Sachs, Petra Paclíková, Martina Brückner, Vítězslav Bryja, Jürgen Behrens, Dominic B Bernkopf
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
dishevelled
DVL2
Wnt signaling
biomolecular condensates
paralogs
Online Access:https://elifesciences.org/articles/96841
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https://elifesciences.org/articles/96841

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