Genetics of mycobacterial adaptation to selective pressure of antituberculous compounds dissected at the in vitro and in vivo levels

Genetics of mycobacterial adaptation to selective pressure of antituberculous compounds dissected at the in vitro and in vivo levels

BACKGROUND: Different spontaneous mutations emerge in Mycobacterium tuberculosis and those beneficial for bacterial survival are selected leading to bacterial drug resistance, tolerance and ultimately - persistence. AIM: To study M. tuberculosis genetic variation in response to selective pressure of...

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Main Authors: Igor Mokrousov, Tatiana Vinogradova, Natalia Solovieva, Ivaylo Slavchev, Marine Dogonadze, Sergei Chekrygin, Dmitry Polev, Anna Vyazovaya, Georgi Dobrikov, Violina T. Angelova, Violeta Valcheva, Viacheslav Zhuravlev
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Mycobacterium tuberculosis
drug resistance
drug tolerance
mutagenesis
spontaneous mutation
murine model
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716524001954
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