Localized COUP‐TFII pDNA Delivery Modulates Stem/Progenitor Cell Differentiation to Enhance Endothelialization and Inhibit Calcification of Decellularized Allografts

Localized COUP‐TFII pDNA Delivery Modulates Stem/Progenitor Cell Differentiation to Enhance Endothelialization and Inhibit Calcification of Decellularized Allografts

Abstract Decellularized allografts have emerged as promising candidates for vascular bypass grafting, owing to their inherent bioactivity and minimal immunogenicity. However, graft failure that results from suboptimal regeneration and pathological remodeling has hindered their clinical adoption. Rec...

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Bibliographic Details
Main Authors: Mengmeng Xing, Fei Wang, Ruowen Chu, He Wang, Yuyao Sun, Meng Qian, Huan Jiang, Adam C. Midgley, Guohao Dai, Qiang Zhao
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
calcification
COUP‐TFII
decellularized allografts
endothelial differentiation
stem/progenitor cells (SPCs)
Online Access:https://doi.org/10.1002/advs.202409744
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