Microglial Nrf2-mediated lipid and iron metabolism reprogramming promotes remyelination during white matter ischemia

Microglial Nrf2-mediated lipid and iron metabolism reprogramming promotes remyelination during white matter ischemia

Background: Oxidative stress and microglial activation are critical pathomechanisms in ischemic white matter injury. Microglia, as resident immune cells in the brain, are the main cells undergoing oxidative stress response. However, the role and molecular mechanism of oxidative stress in microglia h...

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Main Authors: Hang Zhang, Sheng Yang, Yi-Lin Lu, Luo-Qi Zhou, Ming-Hao Dong, Yun-Hui Chu, Xiao-Wei Pang, Lian Chen, Lu-Lu Xu, Lu-Yang Zhang, Li-Fang Zhu, Ting Xu, Wei Wang, Ke Shang, Dai-Shi Tian, Chuan Qin
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Redox Biology
Subjects:
Chronic cerebral hypoperfusion
Oxidative stress
Microglia
Nrf2
Lipid metabolism
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004518
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