Targeted delivery of BACE1 siRNA for synergistic treatment of Alzheimer's disease

Targeted delivery of BACE1 siRNA for synergistic treatment of Alzheimer's disease

Abstract Background The deposition of toxic aggregated amyloid-β (Aβ), resulting from continuous cleavage of amyloid precursor protein (APP) by β-site APP cleaving enzyme 1 (BACE1) and γ-secretase, is a key pathogenic event in Alzheimer's disease (AD). Small interfering RNAs (siRNA) have shown...

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Main Authors: Zhaohan Li, Jun Yang, Jianan Li, Shuxuan Zhao, Shaoping Jiang, Weimin Liu, Xinjian Li, Simeng Zhang, Haiyan Du, Junjun Ni, Yuanyu Huang, Hong Qing, Shaobo Ruan
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Translational Neurodegeneration
Subjects:
Microglia
Alzheimer's disease
Nanomedicine
siRNA
Blood–brain barrier
BACE1
Online Access:https://doi.org/10.1186/s40035-025-00503-7
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