Recent development of micro-nano carriers for oral antineoplastic drug delivery
Chemotherapy is widely recognized as a highly efficacious modality for cancer treatment, involving the administration of chemotherapeutic agents to target and eradicate tumor cells. Currently, oral administration stands as the prevailing and widely utilized method of delivering chemotherapy drugs. H...
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000031 |
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| author | Hongzheng Li Xiang Chen Shangrui Rao Minyu Zhou Jianhua Lu Danna Liang Bingzi Zhu Letian Meng Ji Lin Xiaoya Ding Qingfei Zhang Danhong Hu |
| author_facet | Hongzheng Li Xiang Chen Shangrui Rao Minyu Zhou Jianhua Lu Danna Liang Bingzi Zhu Letian Meng Ji Lin Xiaoya Ding Qingfei Zhang Danhong Hu |
| author_sort | Hongzheng Li |
| collection | DOAJ |
| description | Chemotherapy is widely recognized as a highly efficacious modality for cancer treatment, involving the administration of chemotherapeutic agents to target and eradicate tumor cells. Currently, oral administration stands as the prevailing and widely utilized method of delivering chemotherapy drugs. However, the majority of anti-tumor medications exhibit limited solubility and permeability, and poor stability in harsh gastrointestinal environments, thereby impeding their therapeutic efficacy for chemotherapy. Therefore, more and more micro-nano drug delivery carriers have been developed and used to effectively deliver anti-cancer drugs, which can overcome physiological barriers, facilitate oral administration, and ultimately improve drug efficacy. In this paper, we first discuss the effects of various biological barriers on micro-nano drug carriers and oral administration approach. Then, the development of micro-nano drug carriers based on various biomedical components, such as micelles, dendrimers, hydrogels, liposomes, inorganic nanoparticles, etc. were introduced. Finally, the current dilemma and the potential of oral drug delivery for clinical treatment were discussed. The primary objective of this review is to introduce various oral delivery methods and serve as a point of reference for the advancement of novel oral delivery carriers, with the ultimate goal of informing the development of future clinical applications. |
| format | Article |
| id | doaj-art-d49297d748294178b73cf7062e7fbfb7 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-d49297d748294178b73cf7062e7fbfb72025-01-17T04:52:15ZengElsevierMaterials Today Bio2590-00642025-02-0130101445Recent development of micro-nano carriers for oral antineoplastic drug deliveryHongzheng Li0Xiang Chen1Shangrui Rao2Minyu Zhou3Jianhua Lu4Danna Liang5Bingzi Zhu6Letian Meng7Ji Lin8Xiaoya Ding9Qingfei Zhang10Danhong Hu11Department of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China; Pharmaceutical Sciences Laboratory, Åbo Akademi University, Turku, 20520, FinlandDepartment of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, ChinaDepartment of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China; Pharmaceutical Sciences Laboratory, Åbo Akademi University, Turku, 20520, FinlandDepartment of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, ChinaDepartment of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, ChinaDepartment of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China; Pharmaceutical Sciences Laboratory, Åbo Akademi University, Turku, 20520, FinlandDepartment of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, ChinaDepartment of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, ChinaDepartment of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, ChinaWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325000, China; Corresponding author.Department of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325000, China; Corresponding author. Department of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China.Department of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China; Corresponding author.Chemotherapy is widely recognized as a highly efficacious modality for cancer treatment, involving the administration of chemotherapeutic agents to target and eradicate tumor cells. Currently, oral administration stands as the prevailing and widely utilized method of delivering chemotherapy drugs. However, the majority of anti-tumor medications exhibit limited solubility and permeability, and poor stability in harsh gastrointestinal environments, thereby impeding their therapeutic efficacy for chemotherapy. Therefore, more and more micro-nano drug delivery carriers have been developed and used to effectively deliver anti-cancer drugs, which can overcome physiological barriers, facilitate oral administration, and ultimately improve drug efficacy. In this paper, we first discuss the effects of various biological barriers on micro-nano drug carriers and oral administration approach. Then, the development of micro-nano drug carriers based on various biomedical components, such as micelles, dendrimers, hydrogels, liposomes, inorganic nanoparticles, etc. were introduced. Finally, the current dilemma and the potential of oral drug delivery for clinical treatment were discussed. The primary objective of this review is to introduce various oral delivery methods and serve as a point of reference for the advancement of novel oral delivery carriers, with the ultimate goal of informing the development of future clinical applications.http://www.sciencedirect.com/science/article/pii/S2590006425000031Micro-nano drug carrierOral administrationAntineoplasticCancer therapy |
| spellingShingle | Hongzheng Li Xiang Chen Shangrui Rao Minyu Zhou Jianhua Lu Danna Liang Bingzi Zhu Letian Meng Ji Lin Xiaoya Ding Qingfei Zhang Danhong Hu Recent development of micro-nano carriers for oral antineoplastic drug delivery Materials Today Bio Micro-nano drug carrier Oral administration Antineoplastic Cancer therapy |
| title | Recent development of micro-nano carriers for oral antineoplastic drug delivery |
| title_full | Recent development of micro-nano carriers for oral antineoplastic drug delivery |
| title_fullStr | Recent development of micro-nano carriers for oral antineoplastic drug delivery |
| title_full_unstemmed | Recent development of micro-nano carriers for oral antineoplastic drug delivery |
| title_short | Recent development of micro-nano carriers for oral antineoplastic drug delivery |
| title_sort | recent development of micro nano carriers for oral antineoplastic drug delivery |
| topic | Micro-nano drug carrier Oral administration Antineoplastic Cancer therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000031 |
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