Polygenic risk scores for prostate cancer: Comparative evaluations in UK and Australian cohorts

Polygenic risk scores for prostate cancer: Comparative evaluations in UK and Australian cohorts

Summary: Risk-based approaches offer promise for enhancing early detection of prostate cancer. Polygenic risk scores (PGSs) have emerged as a potential approach for risk stratification, though their performance varies by population. We evaluated nine PGSs (four existing, five new) for predicting 5-y...

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Bibliographic Details
Main Authors: Hamzeh M. Tanha, Matthew H. Law, Nathan Ingold, Philip Ly, Catherine M. Olsen, Nirmala Pandeya, David P. Smith, Robert J. MacInnis, David C. Whiteman, Anne E. Cust, Julia Steinberg
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:HGG Advances
Subjects:
age-specific risk
Australia
cohort study
genomic risk score
polygenic risk score
prostate cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247725000806
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http://www.sciencedirect.com/science/article/pii/S2666247725000806

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