Gastrodin attenuates diabetic cardiomyopathy characterized by myocardial fibrosis by inhibiting the KLK8-PAR1 signaling axis

Gastrodin attenuates diabetic cardiomyopathy characterized by myocardial fibrosis by inhibiting the KLK8-PAR1 signaling axis

Abstract Background Diabetic cardiomyopathy (DCM), characterized by myocardial fibrosis, is a major cause of mortality and morbidity in diabetic patients; the inhibition of cardiac fibrosis is a fundamental strategy for treating DCM. Gastrodin (GAS), a compound extracted from Gastrodia elata protect...

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Bibliographic Details
Main Authors: MingShan Zhang, YuFei Zhang, JingGang He, XinRui Wang, YinYin Wang, LinYan Li, Ling Tao, Min Zhang, Xiangchun Shen
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Chinese Medicine
Subjects:
Diabetic cardiomyopathy
Myocardial fibrosis
Gastrodin
KLK8
Online Access:https://doi.org/10.1186/s13020-024-01035-4
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https://doi.org/10.1186/s13020-024-01035-4

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