Effects of vitamin c and vitamin e applications on wound healing and tissue mineral and hydroxyprolin levels in guinea pig
<b>Aim:</b> This study was performed for investigating the effects of vitamin E and vitamin C on guinea pig wound healing and tissue hydroxi-proline, iron (Fe), copper (Cu) and zinc (Zn) levels.<p> <b>Materials and Methods:</b> A totally of 84 guinea pig were divided in...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=853 |
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| _version_ | 1841564729649135616 |
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| author | Saliha Filiz Pekcici Çuhadar Seyfullah Haliloğlu |
| author_facet | Saliha Filiz Pekcici Çuhadar Seyfullah Haliloğlu |
| author_sort | Saliha Filiz Pekcici Çuhadar |
| collection | DOAJ |
| description | <b>Aim:</b> This study was performed for investigating the effects
of vitamin E and vitamin C on guinea pig wound healing and
tissue hydroxi-proline, iron (Fe), copper (Cu) and zinc (Zn)
levels.<p>
<b>Materials and Methods:</b> A totally of 84 guinea pig were
divided into four groups; the control group (saline, SC), vitamin
C (150 mg/kg, SC), vitamin E (150 mg/kg, SC) and
vitamin C + vitamin E groups. Vitamin and saline injections
were applied 4 days before and 1, 4 and 7 days after the
wound incision. A four centimeters full thickness skin incision
wound was created on the lateral lumbar area. The
wound area closed with basic separate sutures and leaved
open to air. Seven rats from each group were sacrificed on
the days of 4, 7 and 10 after the incisions. Wound tissue histopathologic
exam was done and tissues hydroxi-proline,
Fe, Cu and Zn levels were measured.<p>
<b>Results:</b> Tissue hydroxi-proline levels were highest at 7th
day in all groups and tissue hydroxi-proline level was negative
correlated with Cu and Zn levels. In the histopathologic
examination at 4th day of incision, while reepithelisation
was lowest in the vitamin E group, reepithelisation and fibroblast
activity were highest in the vitamin C group. Reepithelisation
was highest on vitamin C + E group at the 7th
day of the incision.<p>
<b>Conclusion:</b> Vitamin C alone or vitamin C + E administrations
may be positively effective on the healing of incisions. |
| format | Article |
| id | doaj-art-d45bfab94a4a4194892a18fac3e798c6 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-d45bfab94a4a4194892a18fac3e798c62025-01-02T22:36:24ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532828793853Effects of vitamin c and vitamin e applications on wound healing and tissue mineral and hydroxyprolin levels in guinea pigSaliha Filiz Pekcici Çuhadar0Seyfullah Haliloğlu1Cumhuriyet İlköğretim OkuluSelçuk Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, Konya, Türkiye<b>Aim:</b> This study was performed for investigating the effects of vitamin E and vitamin C on guinea pig wound healing and tissue hydroxi-proline, iron (Fe), copper (Cu) and zinc (Zn) levels.<p> <b>Materials and Methods:</b> A totally of 84 guinea pig were divided into four groups; the control group (saline, SC), vitamin C (150 mg/kg, SC), vitamin E (150 mg/kg, SC) and vitamin C + vitamin E groups. Vitamin and saline injections were applied 4 days before and 1, 4 and 7 days after the wound incision. A four centimeters full thickness skin incision wound was created on the lateral lumbar area. The wound area closed with basic separate sutures and leaved open to air. Seven rats from each group were sacrificed on the days of 4, 7 and 10 after the incisions. Wound tissue histopathologic exam was done and tissues hydroxi-proline, Fe, Cu and Zn levels were measured.<p> <b>Results:</b> Tissue hydroxi-proline levels were highest at 7th day in all groups and tissue hydroxi-proline level was negative correlated with Cu and Zn levels. In the histopathologic examination at 4th day of incision, while reepithelisation was lowest in the vitamin E group, reepithelisation and fibroblast activity were highest in the vitamin C group. Reepithelisation was highest on vitamin C + E group at the 7th day of the incision.<p> <b>Conclusion:</b> Vitamin C alone or vitamin C + E administrations may be positively effective on the healing of incisions.http://eurasianjvetsci.org/pdf.php3?id=853wound healingvitamin cvitamin ehydroxyprolinmineral |
| spellingShingle | Saliha Filiz Pekcici Çuhadar Seyfullah Haliloğlu Effects of vitamin c and vitamin e applications on wound healing and tissue mineral and hydroxyprolin levels in guinea pig Eurasian Journal of Veterinary Sciences wound healing vitamin c vitamin e hydroxyprolin mineral |
| title | Effects of vitamin c and vitamin e applications on wound healing and tissue mineral and hydroxyprolin levels in guinea pig |
| title_full | Effects of vitamin c and vitamin e applications on wound healing and tissue mineral and hydroxyprolin levels in guinea pig |
| title_fullStr | Effects of vitamin c and vitamin e applications on wound healing and tissue mineral and hydroxyprolin levels in guinea pig |
| title_full_unstemmed | Effects of vitamin c and vitamin e applications on wound healing and tissue mineral and hydroxyprolin levels in guinea pig |
| title_short | Effects of vitamin c and vitamin e applications on wound healing and tissue mineral and hydroxyprolin levels in guinea pig |
| title_sort | effects of vitamin c and vitamin e applications on wound healing and tissue mineral and hydroxyprolin levels in guinea pig |
| topic | wound healing vitamin c vitamin e hydroxyprolin mineral |
| url | http://eurasianjvetsci.org/pdf.php3?id=853 |
| work_keys_str_mv | AT salihafilizpekcicicuhadar effectsofvitamincandvitamineapplicationsonwoundhealingandtissuemineralandhydroxyprolinlevelsinguineapig AT seyfullahhaliloglu effectsofvitamincandvitamineapplicationsonwoundhealingandtissuemineralandhydroxyprolinlevelsinguineapig |