Effects of vitamin c and vitamin e applications on wound healing and tissue mineral and hydroxyprolin levels in guinea pig
<b>Aim:</b> This study was performed for investigating the effects of vitamin E and vitamin C on guinea pig wound healing and tissue hydroxi-proline, iron (Fe), copper (Cu) and zinc (Zn) levels.<p> <b>Materials and Methods:</b> A totally of 84 guinea pig were divided in...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=853 |
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| Summary: | <b>Aim:</b> This study was performed for investigating the effects
of vitamin E and vitamin C on guinea pig wound healing and
tissue hydroxi-proline, iron (Fe), copper (Cu) and zinc (Zn)
levels.<p>
<b>Materials and Methods:</b> A totally of 84 guinea pig were
divided into four groups; the control group (saline, SC), vitamin
C (150 mg/kg, SC), vitamin E (150 mg/kg, SC) and
vitamin C + vitamin E groups. Vitamin and saline injections
were applied 4 days before and 1, 4 and 7 days after the
wound incision. A four centimeters full thickness skin incision
wound was created on the lateral lumbar area. The
wound area closed with basic separate sutures and leaved
open to air. Seven rats from each group were sacrificed on
the days of 4, 7 and 10 after the incisions. Wound tissue histopathologic
exam was done and tissues hydroxi-proline,
Fe, Cu and Zn levels were measured.<p>
<b>Results:</b> Tissue hydroxi-proline levels were highest at 7th
day in all groups and tissue hydroxi-proline level was negative
correlated with Cu and Zn levels. In the histopathologic
examination at 4th day of incision, while reepithelisation
was lowest in the vitamin E group, reepithelisation and fibroblast
activity were highest in the vitamin C group. Reepithelisation
was highest on vitamin C + E group at the 7th
day of the incision.<p>
<b>Conclusion:</b> Vitamin C alone or vitamin C + E administrations
may be positively effective on the healing of incisions. |
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| ISSN: | 1309-6958 2146-1953 |