A highly efficient heterologous expression platform to facilitate the production of microbial natural products in Streptomyces

A highly efficient heterologous expression platform to facilitate the production of microbial natural products in Streptomyces

Abstract Background Heterologous expression in Streptomyces provides a platform for mining natural products (NPs) encoded by cryptic biosynthetic gene clusters (BGCs) of bacteria. The BGCs are first engineered in hosts with robust recombineering systems, such as Escherichia coli, followed by express...

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Main Authors: Xiuling Wang, Ping Lin, Qiyao Shen, Xueyan Feng, Shouying Xu, Qijun Zhang, Yang Liu, Cailing Ren, Daojing Yong, Qiong Duan, Liujie Huo, Youming Zhang, Gang Li, Jun Fu, Ruijuan Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Microbial Cell Factories
Subjects:
Heterologous expression
Biosynthetic gene cluster
Transfer
Chassis strain
Integration
Online Access:https://doi.org/10.1186/s12934-025-02722-z
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https://doi.org/10.1186/s12934-025-02722-z

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