Harnessing NKG2D CAR-T cells with radiotherapy: a novel approach for esophageal squamous cell carcinoma treatment

Harnessing NKG2D CAR-T cells with radiotherapy: a novel approach for esophageal squamous cell carcinoma treatment

BackgroundEsophageal squamous cell carcinoma (ESCC) represents a highly aggressive malignancy with poor prognosis and limited therapeutic advancements. While chimeric antigen receptor (CAR)-T-cell therapy has revolutionized cancer treatment, its application in ESCC remains poorly explored. This stud...

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Bibliographic Details
Main Authors: Tianyu Liu, Liyuan Fan, Weicheng Huang, Pengxiang Chen, Yuchen Liu, Shuyun Wang, Kaiyue Guo, Yufeng Cheng, Yali Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
NKG2D
CAR-T cells
radiotherapy
combination treatment
ESCC
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589379/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589379/full

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