The evaluation of pharmacokinetic parameters of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide and its metabolites in rat plasma

The evaluation of pharmacokinetic parameters of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide and its metabolites in rat plasma

Introduction: 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide (ODASA) is a new pharmacologically activecompound, which is capable of reducing intraocular pressure by inhibiting carbonic anhydrase II. It is necessary to calculate the pharmacokinetic parameters of this compound and its metabolit...

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Main Authors: Alexander L. Khokhlov, Ilya I. Yaichkov, Anton A. Shetnev, Mikhail K. Korsakov, Nikita N. Volkhin, Sergey S. Petukhov, Alena N. Tyushina, Olga E. Lasaryanz
Format: Article
Language:English
Published: Belgorod National Research University 2024-12-01
Series:Research Results in Pharmacology
Subjects:
hplc-ms/ms
plasma
stabilization
validation
pharmacokinetics
bioavailability
rats
carbonic anhydrase ii inhibitor
n-hydroxysulfonamide
Online Access:https://rrpharmacology.ru/index.php/journal/article/view/523
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